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<p>Trauma Induced Coagulopathy</p>

<p>Eduardo Gonzalez, Hunter B. Moore, Ernest E. Moore</p>

<p>&nbsp;</p>

<p><b>Table of Contents</b></p>

<p>&nbsp;</p>

<p>·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Foreword</p>

<p><i>Kenneth Mann</i></p>

<p>&nbsp;</p>

<p>·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Preface</p>

<p><i>Ernest E. Moore, Hunter B. Moore, Eduardo Gonzalez</i></p>

<p><b>&nbsp;</b></p>

<p>·&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Introduction: Historical Perspective: History of Trauma Induced Coagulopathy</p>

<p><i>Ernest E. Moore, Eduardo Gonzalez, Hunter B. Moore</i></p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><b>Part 1: Physiology of Hemostasis</b></p>

<p>Chapter 1: Cell-Mediated Hemostasis</p>

<p><i>Maureane Hoffman</i></p>

<p>&nbsp;</p>

<p>Chapter 2: Antithrombin Contributions to Physiological Hemostasis and Thrombosis Prevention, and its Dysregulation in Trauma and TIC</p>

<p><i>Susan C. Bock</i></p>

<p>&nbsp;</p>

Chapter 3: Physiology of Hemostasis: Plasmin-antiplasmin system</p>

<p><i>Nicola J Mutch, Nuala A Booth</i></p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><b>Part 2: Pathogenesis of Trauma Induced Coagulopathy</b></p>

<p>Chapter 4: Thrombin Formation</p>

<p><i>Shekhar Kumar, Sriram Krishnaswamy</i></p>

<p>&nbsp;</p>

<p>Chapter 5: Fibrinogen</p>

<p><i>Eduardo Gonzalez, Ernest E. Moore, Hunter B. Moore</i></p>

<p>&nbsp;</p>

<p>Chapter 6: Activated Protein C</p>

<p><i>Mitchell Jay Cohen, Benjamin M. Howard</i></p>

<p>&nbsp;</p>

Chapter 7: Pathogenesis of Trauma Induced Coagulopathy: The Endothelium</p>

<p><i>Pär I. Johansson, Sisse R. Ostrowski</i></p>

<p>&nbsp;</p>

<p>Chapter 8: Platelets</p>

<p><i>Scott L. Diamond</i></p>

<p>&nbsp;</p>

<p>Chapter 9: Fibrinolysis</p>

<p><i>Hunter B. Moore, Ernest E. Moore, Eduardo Gonzalez</i></p>

<p>&nbsp;</p>

<p>Chapter 10: Neutrophils, Inflammation and Innate Immunity in Trauma-Induced Coagulopathy</p>

<p><i>Christopher D. Barrett, Michael B. Yaffe</i></p>

<p>&nbsp;</p>

<p>Chapter 11: DAMPs: Damage-Associated Molecular Pattern Molecules in Hemostasis</p>

<p><i>Charles T. Esmon</i></p>

<p>&nbsp;< <p>Chapter 12: The Complement System and Coagulation</p>

<p><i>Narcis I. Popescu, Florea Lupu</i></p>

<p>&nbsp;</p>

<p>Chapter 13: Disseminated Intravascular Coagulation</p>

<p><i>Satoshi Gando</i></p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><b>Part 3: Coagulation Assessment in Trauma Induced Coagulopathy</b></p>

<p>Chapter 14: Prothrombin and Partial Thromboplastin Time</p>

<p><i>Ruchika Goel, Paul M Ness</i></p>

<p>&nbsp;</p>

<p>Chapter 15: Fibrinogen Assays</p>

<p><i>Christoph J. Schlimp, Herbert Schöchl</i></p>

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </p>

<p>Chapter 16: Platelet Aggregometry</p>

<p><i>Taizo Nakano, Jorge Di Paola</i></p>

<p>&nbsp;</p>

<p>Chapter 17: Thrombelastography</p>

<p><i>Eduardo Gonzalez, Ernest E. Moore, Hunter B. Moore</i></p>

<p>&nbsp;</p>

<p>Chapter 18: Rotational Thromboelastometry (ROTEM®)</p>

<p><i>Klaus Görlinger, Daniel Dirkmann, Alexander A. Hanke</i></p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><b>Part 4: Management of Trauma Induced Coagulopathy</b></p>

<p>Chapter 19: Red Blood Cell: Manufacture, Storage, and Transfusion</p>

<p><i>F. Bernadette West, Marguerite R. Kelher, Christopher C. Silliman</i></p>

<p>&nbsp;</p>

<p>Chapter 20: Plasma Transfusion</p>

<p><i>Ryan A. Lawless, John B. Holcomb</i></p>

<p>&nbsp;</p>

<p>Chapter 21: Cryoprecipitate Transfusion</p>

<p><i>Jeannie L. Callum, Bartolomeu Nascimento</i></p>

<p>&nbsp;</p>

<p>Chapter 22: The Evolving Role of Platelets in Trauma Care</p>

<p><i>Andrew P. Cap, Todd Getz, Philip Spinella, Heather Pidcoke</i></p>

<p>&nbsp;</p>

<p>Chapter 23: Massive Transfusion Protocols</p>

<p><i>Alexis M. Moren, Samantha J. Underwood, Martin A. Schreiber</i></p>

<p>&nbsp;</p>

<p>Chapter 24: Fibrinogen and Clotting Factor Replacement</p>

<p><i>Massimo Franchini</i></p>

<p>&nbsp;</p>

<p>Chapter 25: Anti-Fibrinolytics</p>

<p><i>Dominik F. Draxler, Robert L. Medcalf, Russell L. Gruen</i></p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><b>Part 5: Post-injury Hypercoagulability</b></p>

<p>Chapter 26: Venous Thromboembolism</p>

<p><i>Steven R. Shackford, C. Beth Sise</i></p>

<p>&nbsp;</p>

<p>Chapter 27: Congenital and Acquired Hypercoagulable States</p>

<p><i>Joseph Emmerich</i></p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><b>Part 6: Organ-specific Coagulopathy</b></p>

Chapter 28: Coagulopathy in Traumatic Brain Injury (TBI)</p>

<p><i>Marc Maegele</i></p>

<p>&nbsp;</p>

<p>Chapter 29: Liver Disease</p>

<p><i>Shahzaib Ahmad, Beverly J Hunt</i></p>

<p>&nbsp;</p>

<p>Chapter 30: Hemostatic Abnormalities in Renal Disease </p>

<p><i>Michael P. Chapman, Anirban Banerjee, Ernest E. Moore</i></p>

<p>&nbsp;</p>

<p>&nbsp;</p>

<p><b>Part 7: Trauma Induced Coagulopathy in Special Populations</b></p>

<p>Chapter 31: Pediatrics</p>

<p><i>Robert I. Parker</i></p>

<p>&nbsp;</p>

<Chapter 32: Pregnancy</p>

<p><i>Philippe de Moerloose, T. Marchetti, A. Casini</i></p>

<p>&nbsp;</p>

<p>Chapter 33: Management of Chronically Anticoagulated Patients</p>

<p><i>Jerrold H. Levy</i></p>

<p><b>&nbsp;</b></p>

<p><b>&nbsp;</b></p>

<p><b>Part 8: Research of Trauma Induced Coagulopathy</b></p>

<p>Chapter 34: Animal Models</p>

<p><i>Ted Bambakidis, Martin Sillesen, Hasan B. Alam</i></p>

<p>&nbsp;</p>

<p>Chapter 35: Mathematical Models of Hemostasis</p>

<p><i>Keith B. Neeves, Karin Leiderman</i></p>

<p>&nbsp;</p>

<p>&nbsp;</p>

Ernest E. Moore, MD is Editor, Journal of Trauma and Acute Care Surgery (LWW)

This text is aimed at defining the current concepts that define trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It will serve as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader will have full understanding of the tests that are used to study trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications&nbsp;are reviewed in detail.<div><br></div><div>Trauma Induced Coagulopathy will also be a valuable source for quick reference to the clinician that is faced with specific clinical challenges when managing coagulopathy.</div>

<p>Outlines the current concepts that define trauma induced coagulopathy</p><p>Written by experts in the field</p><p>Provides a valuable source for quick reference to the clinician that is faced with specific clinical challenges when managing coagulopathy</p><p>Includes supplementary material: sn.pub/extras</p>

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