Details

<p>Part 1. Epidemiology-Prevalence and
Transmission routes of H. pylori.- Part 2. Pathophysiology.- 1) Colonization of
H. pylori in the stomach.- 2) Brief description of Pathophysiology.- 3) Immune
mechanism.- 4) Change of acid secretion, ghrelin and leptin by H. pylori.- 5) H.
pylori virulence factors.- A: toxin (CagA, VacA, DupA, OipA, IceA).- B: genetic
polymorphism of toxin and disease.- 6) Host factors: genetic polymorphism,
etc.- Part 3. Diagnosis.- 1) Serology.- 2) Histology.- 3) Culture.- 4) UBT.- 5)
Stool antigen.- 6) Specific conditions.- A: Children.- B: Bleeding.-&nbsp;Part
4. Symptom.- 1)Symptom of acute and chronic H. pylori infection.- Part 5.
Disease.- 1) Atrophic gastritis and Intestinal metaplasia.- 2) Functional dyspepsia.-
3) Peptic ulcer.- 4) MALToma.- 5) Gastric cancer.- A: Synopsis and Epidemiology
of gastric cancer.- B1: Pathogenesis: i.Genetic alternation (mutations in
tumor-related genes) induced by Activation-induced cytidine deaminase (AID).- B2:
Pathogenesis: ii. Epigenetic mechanisms: aberrant DNA methylation, microRNA.- B3:
Pathogenesis:iii. Macrophage inhibitory factor (MIF).- B4: Pathogenesis: iv.
Epidermal mesenchyme transition (EMT).- B5: Pathogenesis: v. ABO blood type.- B6:
Pathogenesis: vi. First relatives of gastric cancer.- C: H. pylori-negative
gastric cancer.- 6) Gastroesophageal reflux disease (GERD).- 7) NSAID-induced
gastropathy and H. pylori infection.- 8) Extraintestinal manifestations of H.
pylori infection.- A: Iron deficiency anemia.- B: Idiopathic thrombocytopenic
purpura.- C: Heart disease.- D: Atopy and allergy.-&nbsp;Part 6. Antibiotic
resistance.- 1) Synopsis of antibiotic resistance.- 2) Clarithromycin.- 3)
Amoxicillin.- 4) Quinolone.- 5) Metronidazole.- Part 7. Treatment.- 1) Synopsis
of antibiotic treatment.- 2) Triple therapy.- 3) Quadruple therapy.- 4)
Sequential therapy.- 5) Concomitant therapy.- 6) Tailored therapy based on
antibiotic resistance.- 7) Levofloxacin or rifabutin based triple therapy.- 8)
Probiotics.- 9) Treatment guidelines.- 10) Screening method of early gastric
cancer.- 11) Recrudescence and reinfection.-&nbsp;Part 8. Consequences of H.
pylori eradication.- 1) Peptic ulcer disease.- 2) atrophic gastritis and
Intestinal metaplasia.- 3) Gastric cancer.- Part 9. The effect of H. pylori on
the other microbiota of stomach.- The effect of H. pylori on the other
microbiota of stomach.- Part 10. Animal model- H. pylori, H. felis.</p>

Nayoung Kim MD Ph.D., Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Republic of Korea

<p>This book presents the
current state of knowledge regarding the ability of <i>Helicobacter pylori</i> to colonize the gastrointestinal tract, the
global epidemiology of <i>H. pylori</i>
infection, transmission routes, the pathophysiology of <i>H. pylori</i>-related gastroduodenal and other diseases, diagnosis and
treatment methods, guidelines for eradication, antibiotic resistance, the
reinfection rate after <i>H. pylori </i>eradication,
and animal models of <i>H. pylori</i> or
related <i>Helicobacter</i> infection. The
aim is to equip readers around the world with the understanding required in
order to implement effective methods of <i>H.
pylori</i> eradication and to enhance clinical outcomes for patients. The text
is clearly written and is complemented by many helpful illustrations. This book
will be a great asset in clinical practice for all practitioners who are
involved in caring for patients with <i>H.
pylori</i>-related diseases or have an interest in the subject. It will also be
a useful source of information for medical students and for intelligent laypeople
seeking information on<i> H. pylori</i>.</p>

Presents the latest knowledge on all aspects of H. pylori infection and its consequences Offers detailed guidance on diagnosis and treatment Covers epidemiology, pathophysiology, antibiotic resistance, and reinfection rates