Details

Organelles in Disease

Reviews of Physiology, Biochemistry and Pharmacology, Band 185

von: Stine Helene Falsig Pedersen, Diane L. Barber
139,09 €
Verlag:	Springer
Format:	PDF
Veröffentl.:	27.01.2023
ISBN/EAN:	9783031225956
Sprache:	englisch

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Beschreibungen

Titelbeschreibung

<p>This book sheds light on how dysregulated organelle functions contribute to the pathology and progression of human diseases. To offer a broad perspective, they discuss basic, translational, and clinical aspects across scales, from molecules to cells, tissues and organisms. Rather than providing a comprehensive introduction to the field, the authors focus on recent advances in organelle research, with each chapter inviting readers to consider today’s key questions in the respective field.<br></p><p>This book reviews the endoplasmic reticulum, Golgi Appartus, Lysosomes and other membrane-enclosed organelles, demonstrating how their dysregulated function contributes to various pathologies. The chapters not only offer a platform for new perspectives but also stimulate further investigations.<br></p>

<p>Given the translational nature of this subject, this book is a valuable resource for physiologists and clinicians alike.<br></p><p>Chapter "Lipid Droplets in Cancer" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.<br></p>

Inhaltsverzeichnis

Golgi pH and Ion Homeostasis in Health and Disease.- Stress Granules in Cancer.- Lipid Droplets in Cancer.- Patterns of Ciliation and Ciliary Signaling in Cancer.- Targeting Cancer Lysosomes with Good Old Cationic Amphiphilic Drugs.- Cancer-Related Increases and Decreases in Calcium Signaling at the Endoplasmic Reticulum-Mitochondria Interface (MAMs).- Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases.- Endolysosomal Disorders Affecting the Proximal Tubule of the Kidney: New Mechanistic Insights and Therapeutics.- Endo-Lysosomal Cation Channels and Infectious Diseases.

Back cover copy

<p>Golgi pH and Ion Homeostasis in Health and Disease </p>

<i>Elham Khosrowabadi and Sakari Kellokumpu</i><div><br></div><div>Stress Granules in Cancer <br></div><div> <i>Min-Seok Song and Elda Grabocka</i><i><br></i></div><p>Lipid Droplets in Cancer </p>

<i>Toni Petan</i><br><div><p>Patterns of Ciliation and Ciliary Signaling in Cancer</p>

<i>Anna A. Kiseleva, Anna S. Nikonova, and Erica A. Golemis</i><i><br></i></div><p>Targeting Cancer Lysosomes with Good Old Cationic Amphiphilic Drugs </p>

<i>Anne-Marie Ellegaard, Peter Bach, and Marja Jäättelä</i><i><br></i><div><p>Cancer-Related Increases and Decreases in Calcium Signaling at the Endoplasmic Reticulum-Mitochondria Interface (MAMs) </p>

<i>Alberto Danese, Saverio Marchi, Veronica Angela Maria Vitto, Lorenzo Modesti, Sara Leo, Mariusz R. Wieckowski, Carlotta Giorgi, and Paolo Pinton</i><i><br></i></div><div><p>Endosomal Acid-Base Homeostasis in Neurodegenerative Diseases </p>

<i>Hari Prasad and RajiniRao</i></div><div><i><br></i></div><div><div>Endolysosomal Disorders Affecting the Proximal Tubule of the Kidney: New Mechanistic Insights and Therapeutics</div><div><i>Beatrice Paola Festa, Marine Berquez, Daniela Nieri, and Alessandro Luciani</i></div><div><br></div><div><div>Endo-Lysosomal Cation Channels and Infectious Diseases </div><div><i>Yu-Kai Chao, Sui-Yuan Chang, and Christian Grimm</i></div></div></div><div><i><br></i></div>Chapter "Lipid Droplets in Cancer" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.<br><div><i></i></div>

Sonderbeitrag

Connects basic cell biology with medical application opportunities Provides insights from both laboratory and clinical research Contributes to a progessive scientific discussion in molecular medicine